博士/教授

TEL/ 0635-8239772

EMAIL/ liumin2@lcu.edu.cn

• 科研方向/物理化学

• 讲授课程

化工原理

• 教育经历

1991.09–1995.07，青岛科技大学/有机化工专业，学士

1998.09–2001.02，北京理工大学/化学工程专业，硕士

2004.09–2007.07，浙江大学/物理化学专业，博士

• 科研项目

靶向DNA纳米结构与化疗-光疗联合药物相互作用的微量热和谱学研究，国家自然科学基金，2021-2024，主持

儿茶素类天然生化调节剂-抗癌药物协同体系与蛋白质相互作用的量热学-谱学研究，国家自然科学基金，2015–2018，主持

多糖类药物载体靶向控释的抗癌药物与靶标DNA相互作用的化学热力学研究，国家自然科学基金，2012–2014，主持

核酸自组装纳米结构共加载茶多酚-化疗药物的热力学研究，省自然科学基金，2021-2023，主持

紫杉醇人血白蛋白纳米粒药物制剂的研究与开发，山东省重点研发计划项目，2016–2018，主持

智能响应型药物载体对难溶性抗癌药物的增溶及靶向控释研究，山东省抗体制药协同创新中心开放课题，2018-2020，主持

• 获奖情况

2021年，聊城大学“光岳英才”第二层次

2019年，山东省高等学校优秀科研成果二等奖

2016年，山东省高等学校优秀科研成果三等奖

2020年，伟德国际betvlctor1946优秀科研成果一等奖

2018年，伟德国际betvlctor1946优秀科研成果二等奖

2017年，伟德国际betvlctor1946优秀科研成果二等奖

• 论著一览

在国内外有较大影响的专业学术期刊上首位或通讯联系人发表论文100余篇。

(1) Tingting Liu; Min Liu*; et al. Co-encapsulation of (−)-epigallocatechin- 3-gallate and piceatannol/oxyresveratrol in -lactoglobulin: effect of ligand–protein binding on the antioxidant activity, stability, solubility and cytotoxicity, Food Funct., 2021, 12, 7126 (SCI 1区,封面文章)

 (2) Yinglin Liu; Min Liu*; et al. Enhanced solubility of bisdemethoxycurcumin by interaction with Tween surfactants: Spectroscopic and coarse-grained molecular dynamics simulation studies, J. Mol. Liq., 2021, 323, 115073 (SCI 2区).

 (3) Danfeng Wang; Min Liu*; et al. Self-assembled DNA nanotrains for targeted delivery of mithramycin dimers coordinated by different metal ions: Effect of binding affinity on drug loading, release and cytotoxicity, J. Mol. Liq., 2021, 339, 116722 (SCI 2区).

 (4) He Liu; Min Liu*; et al. Competitive binding of synergistic antioxidant chlorogenic acid and (-)-epigallocatechin gallate with lysozyme: Insights from multispectroscopic characterization, molecular docking and activity evaluation, J. Mol. Liq., 2021, 341, 117387 (SCI 2区).

(5) Tingting Liu; Min Liu*; et al. Investigation of binary and ternary systems of human serum albumin with oxyresveratrol/piceatannol and/or mitoxantrone by multipectroscopy, molecular docking and cytotoxicity evaluation, J. Mol. Liq., 2020, 311, 113364 (SCI 2区).

(6) Wenxin Pei; Min Liu*; et al. High payload and targeted release of anthracyclines by aptamer-tethered DNA nanotrains – Thermodynamic and release kinetic study, Eur. J. Pharm. Sci., 2020, 148, 105319 (SCI 2区).

(7) Min Liu*; et al. Comparative study on the interaction of oxyresveratrol and piceatannol with trypsin and lysozyme: binding ability, activity and stability, Food Funct., 2019, 10: 8182–8194 (SCI 1区).

(8) Qingying Guo; Min Liu*; et al. Spectroscopic and cytotoxicity studies on the combined interaction of (−)-epigallocatechin-3-gallate and anthracycline drugs with human serum albumin, Spectrochim. Acta A, 2019, 222: 117213 (SCI 2区).

(9) Yabo Shi; Min Liu*; et al. Mutual influence of piceatannol and bisphenol F on their interactionwith pepsin: Insights fromspectroscopic, isothermal titration calorimetry and molecular modeling studies, Spectrochim. Acta A, 2019, 206: 384–395 (SCI 2区).

(10) Chang Cai; Min Liu*; et al. A combined calorimetric, spectroscopic and molecular dynamic simulation study on the inclusion complexation of (E)-piceatannol with hydroxypropyl--cyclodextrin in various alcohol + water cosolvents, J. Chem. Thermodyn., 2019, 132: 341–351 (SCI 2区).

(11) Lixia Yuan; Min Liu*; et al. Calorimetric and spectroscopic studies on the competitive behavior between (−)-epigallocatechin-3-gallate and 5-fluorouracil with human serum albumin, J. Mol. Liq., 2017, 248: 330–339 (SCI 2区).

(12) Lixia Yuan; Min Liu*; et al. Competitive binding of epigallocatechin-3-gallate and 5-fluorouracil to human serum albumin: A fluorescence and circular dichroism study, Spectrochim. Acta A, 2017, 173: 584–592 (SCI 2区).

(13) Min Liu*; et al. Improved stability of (+)-catechin and (-)-epicatechin by complexing with hydroxypropyl-β-cyclodextrin: Effect of pH, temperature and configuration, Food Chem., 2016, 196: 148–154 (SCI 1区).

(14) Chunmei Wang; Min Liu*; et al. Calorimetric and spectroscopic studies on temperature- and pH-dependent interactions of stimuli-responsive poly (N-isopropyl acrylamide) with piceatannol, J. Chem. Thermodyn., 2016, 98: 186–192 (SCI 2区).

(15) Yan Zheng; Min Liu*; et al. Simultaneous determination of enthalpies of dilution and dissociation of protocatechuic acid in aqueous salt solutions by calorimetric measurements, J. Chem. Thermodyn., 2015, 91: 177–185 (SCI 2区) .

• 相关成果

(1)  “紫杉醇人血白蛋白纳米粒药物制剂的研究与开发”鉴定为国际先进水平

(2)  授权专利：一种药物-磷脂/白蛋白复合纳米粒及制备工艺, ZL 201711044667.1；一种尼莫地平固体分散体及其片剂制备方法，ZL 201711390110.3